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James Francis Gusella is a Bullard Professor in Neurogenetics at Harvard University, specializing in molecular genetic strategies to understand nervous system diseases. His research focuses on identifying gene defects linked to conditions such as Huntington's disease and neurofibromatosis through chromosomal location studies, gene identification, and characterization of the mechanisms of action. His work involves utilizing various model systems, including cultured human cells and genetically engineered mice, to explore potential genetic interventions. He currently participates in the Developmental Genome Anatomy Project, which aims to identify genes associated with developmental abnormalities. Gusella's lab actively investigates the pathogenesis of genetic defects tied to autism, Huntington's disease, Parkinson's disease, and neurofibromatosis, employing induced pluripotent stem cells and other model organisms to discover genetic and chemical modifiers that could lead to effective therapies.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).