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James Gusella is a prominent researcher affiliated with the Harvard Stem Cell Institute and Massachusetts General Hospital, who specializes in the investigation of nervous system diseases through molecular genetic strategies. His lab, the Gusella Lab, focuses on understanding the genetic and molecular basis of disorders such as Huntington's disease and other neuropsychiatric conditions. The research encompasses multiple stages, including the determination of chromosomal locations of gene defects, identification of susceptibility genes, and the analysis of their mechanisms in various model systems. The lab employs a diverse array of techniques including genome sequencing and in vitro modeling with human stem cells and engineered mice, aiming to explore potential rational and genetic therapies for these disorders. Gusella is also involved in the Developmental Genome Anatomy Project, where he seeks to identify genetic breakpoints associated with developmental abnormalities. His contributions are vital for improving diagnosis, prevention, and treatment strategies for neurodevelopmental disorders.
Harvard Stem Cell Institute • Boston, MA
Leading research into nervous system diseases using molecular genetic strategies.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.