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James Francis Gusella is a prominent researcher in the field of Neurogenetics at Harvard Medical School and Massachusetts General Hospital. His laboratory focuses on understanding nervous system diseases using molecular genetic strategies. The research involves several stages, beginning with the determination of chromosomal locations of gene defects and susceptibility genes through linkage association studies. Following this, the responsible genes are identified based on phenotypic effects, employing various genome analysis strategies. Gusella's work includes the characterization of mechanisms of action based on analysis of allelic versions of culprit genes in human subjects and model systems, such as cultured human cells and genetically engineered mice. He is also involved in exploring potential rational and genetic therapies for disorders such as autism, Parkinson's disease, Huntington's disease, and neurofibromatosis. Gusella contributes to the Developmental Genome Anatomy Project, which aims to identify genes associated with developmental abnormalities.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.