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James LaBelle is a Professor at the University of Chicago, specializing in Pediatrics-Hematology Oncology. His research primarily focuses on pharmacologically targeting intracellular proteins to induce cancer cell death and manipulate immune responses. LaBelle is currently developing prototype therapeutics aimed at targeting BCL-2 family proteins and cell signaling proteins in immune cells. His lab employs substantial methodology involving actual proteins, peptides, drugs, and biological tools to uncover specific molecular pathways in diseased and normal cells. LaBelle's work is significant in advancing peptide-based therapeutics for immune modulation and cancer treatment, which have traditionally faced challenges in stabilization and delivery to patients. He collaborates closely with nanotechnologists and chemical engineers to overcome these barriers, reflecting his commitment to translating scientific findings into clinical applications for pediatric and adult patients suffering from cancer and related diseases. LaBelle's collaborative approach with fellow scientists and clinicians enhances his research's impact, aiming to make substantial contributions to the treatment of refractory cancers.
Department of Philosophy