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James Mastrianni, MD, PhD, is a professor at the University of Chicago, specializing in neurology and neurobiology. He focuses on Alzheimer’s Disease, neurodegenerative disorders, and prion diseases. As a clinician, Dr. Mastrianni provides diagnostic evaluations and long-term management for patients with Alzheimer’s-related dementias. He leads a special clinic dedicated to evaluating atypical dementias when clear diagnoses cannot be determined. His research, funded by notable organizations such as the National Institutes of Health and Howard Hughes Medical Institute, seeks to understand both animal and human prion diseases, making significant contributions to the understanding of these progressive neurodegenerative conditions. Dr. Mastrianni’s recent studies identified a direct link between prion diseases and Alzheimer's disease, contributing to advancements in gene therapy approaches. An accomplished author, he has published numerous articles in prestigious medical journals and serves as an invited expert reviewer. Beyond his research, he is dedicated to education, mentoring students and residents in the field of neurology.
Department of Philosophy