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Professor James Nathan's research focuses on how cells sense and respond to changes in their oxygen and nutrient environments, with implications for human disease. His lab employs a combination of biochemical and genetic approaches to identify components influencing cellular responses to oxygen metabolites. A central theme of Nathan's work involves understanding the mechanisms through which oxygen-sensing chromatin modifications guide cell-fate decisions via epigenetic and transcriptional pathways. Recent projects have sought to uncover metabolic pathways that influence the activity of 2-oxoglutarate-dependent dioxygenases and their role in regulating the Hypoxia Inducible Factors (HIFs). The interplay between mitochondrial metabolites and cellular iron metabolism has garnered particular attention in his laboratory, with groundbreaking findings on the importance of Vacuolar-ATPase and 2-oxoglutarate dehydrogenase in controlling the HIF response. Nathan's research aims to provide novel insights into oxygen metabolite sensing pathways, ultimately paving the way for new therapeutic targets in inflammatory diseases and cancers.
University of Cambridge • Cambridge
Head of the Nathan Group in the Department of Medicine, focusing on research related to cellular responses to oxygen and metabolites.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.