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James M. Rini is a Professor in the field of Molecular Genetics at the University of Toronto. He specializes in infectious disease microbiology and structural biology, with a notable focus on the study of coronavirus-host cell receptor interactions. His research delves into the role of glycosyltransferases in protein folding and subcellular targeting, employing a structural approach that uses techniques such as x-ray crystallography and electron cryo-microscopy (Cryo-EM). Currently, Professor Rini is investigating the SARS-CoV-2 virus and seasonal coronaviruses responsible for common cold-like symptoms, particularly studying the coronavirus Spike protein complex and its interaction with receptors and neutralizing antibodies. His work aims to elucidate the mechanisms of viral neutralization, immune evasion, and cross-species transmission, contributing to the development of antibody therapeutics and vaccines against SARS-CoV-2. Furthermore, his recent studies on glycosyltransferases focus on the protein-O-glycosyltransferases associated with EGF-like domains primarily in Notch receptor ligands, highlighting the importance of these enzymes in ensuring proper protein folding and targeting, which are crucial for maintaining protein homeostasis in multicellular organisms.
Department of Sociology