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James Shorter is a Professor in the Department of Biochemistry and Biophysics at the University of Pennsylvania's Perelman School of Medicine. His research primarily focuses on protein homeostasis and the mechanisms involved in protein folding and misfolding, specifically in relation to neurodegenerative diseases such as Alzheimer's and Parkinson's. He aims to understand how cells prevent and reverse the formation of misfolded proteins and amyloids, which are associated with various neurodegenerative disorders. His work also investigates the role of molecular chaperones and disaggregases in managing protein aggregation and the implications for disease treatment. Shorter has garnered multiple grants and has published extensively on these subjects. He is an active member of several research and advisory boards within the university, guiding the next generation of researchers and promoting interdisciplinary collaboration.
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