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James W. Wells is a Professor Emeritus at the Leslie Dan Faculty of Pharmacy, University of Toronto. He specializes in the molecular basis of drug targets and diseases, focusing on G protein-mediated transmembrane signaling. His research investigates the interactions between receptors and G proteins, particularly in relation to muscarinic cholinergic receptors in the heart, including the M2 subtype and its mutant variants. Through various biochemical and pharmacological methods, including ultracentrifugation, chromatographic procedures, and gel electrophoresis, he has explored the functional and structural properties of these receptors. His goal is to develop a quantitatively accurate model system to describe the signaling processes and their implications for understanding abnormal functioning associated with G protein-mediated transduction in conditions such as schizophrenia, heart disease, and Alzheimer's disease. Wells' contributions to the field emphasize the importance of precise quantitative descriptions of molecular interactions in pharmacology.
University of Toronto • Toronto, Canada
Retired from the Leslie Dan Faculty of Pharmacy, focusing research on molecular pharmacology.
Department of Sociology