Generate a tailored SOP for Dr. Jamie Fletcher. Improve your application with a focused, well-structured draft.
I am a translational researcher based at the Children's Cancer Institute, leading a team of postdoctoral researchers and students focused on childhood solid tumor neuroblastoma. My research addresses the challenges of high-risk neuroblastoma, particularly the issues surrounding relapse and drug resistance, which contribute to a 50% long-term survival rate. My work aims to understand the biology of neuroblastoma and improve patient survival rates by identifying molecular mechanisms underlying drug resistance and developing small molecule inhibitors targeting these mechanisms. Additionally, I am working on improved pre-clinical testing models for high-risk neuroblastoma, including patient-derived xenograft models, and I model personalized medicine strategies through molecular profiling and ex vivo drug sensitivity screening. My team employs high-throughput drug screening, genomic analysis, mouse models, and tissue-culture based approaches to study drug resistance mechanisms and develop new therapies. My research outputs are published in prestigious journals including JNCI, Cancer Research, and Nature Reviews Cancer.
University of New South Wales • Sydney, Australia
Leading research on neuroblastoma and associated therapies.
Includes Business Intelligence, Enterprise Systems, and Cybersecurity Management streams.