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Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins to engineer new molecules that overcome deficiencies in existing drugs. Integrating cutting-edge tools from structural biophysics and biomolecular engineering, her research focuses on developing innovative platforms for the discovery and design of proteins that can recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of Spangler's interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.
Department of Pathology - PhD in Pathobiology. GRE is not required.