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Janet R. Sparrow is a professor in the Department of Pathology and Cell Biology at Columbia University. Her research focuses on the mechanisms underlying retinal diseases, particularly those related to the accumulation of lipofuscin in retinal pigmented epithelial (RPE) cells. Her major work involves studying the phototoxic effects of the lipofuscin component A2E, exploring its role in blue light-mediated RPE cell death. Moreover, her investigations into the biosynthesis of A2E and the conditions leading to its accelerated accumulation are crucial in understanding age-related macular degeneration (AMD) and Stargardt's disease. Dr. Sparrow has authored numerous publications examining the challenges posed by A2E and its derivatives, linking them to oxidative damage in RPE cells through pathways involving reactive oxygen species and other harmful byproducts. She holds several prestigious awards and has received numerous fellowships for her contributions to retinal research. Dr. Sparrow's lab is dedicated to developing therapeutic strategies targeting the harmful effects of bisretinoids, including the use of antioxidants and gene-based therapies to mitigate RPE cell degeneration.
Columbia University • New York, NY
Leads research focused on retinal degeneration and the biological effects of lipofuscin.
Department of Anthropology (GSAS)