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Janis K. Burkhardt is a Professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania. Her research focuses on the regulation of cytoskeletal dynamics and the immune response, particularly in T cells and dendritic cells. The lab investigates how cytoskeletal control impacts processes such as cell migration, antigen presentation, and immune signaling. Key research interests include understanding the molecular mechanisms of receptor-ligand interactions that trigger cytoskeletal remodeling, which ultimately influences T cell function. Burkhardt's work has identified critical actin regulatory proteins, such as WASP and HS1, which play pivotal roles in immune system functions and diseases. Her lab is also engaged in exploring new perspectives in T cell immunotherapy.
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