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Dr. Jason Holley is a prominent researcher in the field of cellular plasticity and epigenetics. His lab, the Koh Lab at the University of Chicago, focuses on understanding the design principles that regulate cell fate stability versus plasticity. This research is crucial as it sheds light on the mechanisms underlying tumorigenesis and tissue repair. By investigating the role of chromatin in specifying a range of phenotypes and integrating intrinsic and extrinsic cues such as transcription factor activity, chromatin remodeling, and signal transduction, Dr. Holley employs an interdisciplinary approach that combines genetics, genomics, biochemistry, proteomics, and computational modeling. His work aims to elucidate how cellular plasticity can both promote health and drive disease, particularly in the context of tumor formation and tissue adaptation to changing environments.
Department of Philosophy