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Jason S. McLellan specializes in understanding the structure and function of viral proteins, particularly coronaviruses. His research focuses on applying structural information for the rational design of vaccines and therapies against viruses, including SARS-CoV-2, the novel coronavirus that causes COVID-19. McLellan's team collaborated with researchers from the National Institute of Allergy and Infectious Diseases' Vaccine Research Center to design a stabilized version of the SARS-CoV-2 spike protein, which is a key element in the four COVID-19 vaccines that reached Phase 3 clinical trials and were approved for emergency use, including those by Pfizer BioNTech, Moderna, Johnson & Johnson Janssen Pharmaceutica, and Novavax. Additionally, McLellan co-developed a vaccine candidate for RSV (respiratory syncytial virus) that is currently undergoing human trials.
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