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Associate Professor Jason Schnell focuses on understanding the molecular structure and function of proteins critically involved in human health and disease. His research incorporates various tools, with a central reliance on solution nuclear magnetic resonance (NMR) spectroscopy, which facilitates atomic-level studies of protein structures and interactions. Specifically, his lab investigates the DP1/reticulon family of integral membrane proteins that maintain high curvature in tubular endoplasmic reticulum (ER). Dysfunctions in these proteins are linked to neuronal diseases such as Hereditary Spastic Paraplegia. Additionally, he has a long-standing interest in the molecular mechanisms by which Influenza virus proteins function, specifically studying protein-protein and lipid interactions to understand the role of these proteins in the viral life cycle, aiming to identify potential therapeutic targets. He is also exploring the structure and function of chaperone proteins, particularly J-domain proteins, in order to comprehend how they interact with misfolded or unfolded client proteins within the HSP70 machinery. His laboratory collaborates with research groups around the world, including virologists, cell biologists, and computational biologists, to further advance understanding in these critical areas.
Department of Politics and International Relations - Higher Level English requirement.