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Dr. Jean Vance is a Professor in the Department of Medicine at the University of Alberta. Her research focuses on mechanisms of intracellular lipid trafficking in mammalian cells, particularly the role of mitochondria-associated membranes (MAM) in calcium homeostasis and phosphatidylserine (PS) transport. She has generated and characterized mice lacking PS synthases and phosphatidylserine decarboxylase, revealing critical insights into mitochondrial functions and lipid synthesis disorders. Dr. Vance is a major contributor to studies on PS synthase-1 mutations related to Lenz-Majewski syndrome. Her lab investigates cholesterol trafficking in the brain, particularly defects in Niemann-Pick type C disease. Currently, they explore the effects of cyclodextrin on cholesterol homeostasis in neurological contexts. Dr. Vance has served on editorial boards for prominent journals and chaired several significant conferences related to lipid research. She was elected as a Fellow of the Royal Society of Canada in recognition of her contributions to the field.
Department: Mechanical Engineering and Engineering Management