Dr. Jeffery Coller

Biography

Jeffery Coller has made seminal discoveries in the area of messenger RNA stability and translation. His research explores the dynamics of ribosomes in patients, pushing the boundaries in the exciting field of developing novel therapeutics for devastating rare diseases and improving the efficacy of gene therapy manufacturing. Coller studies the essence of life: the translation of the genetic code, leading to fundamental shifts in the understanding of gene expression by demonstrating that the genetic code is a major determinant of mRNA fate in eukaryotes, including humans. His work examines the relationship between mRNA translation—a process by which messenger RNA is synthesized into protein—and mRNA stability, focusing particularly on the pathways underlying mRNA degradation. He investigates the signals at the end of mRNA translation that signal the beginning of mRNA degradation, which holds great potential for novel therapeutics. Coller joined Johns Hopkins University as a Bloomberg Distinguished Professor in 2020 after his tenure at Case Western Reserve University.

Research Interests

Experience