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Jeffrey Dvorin is an Associate Professor in the Department of Pediatrics at Harvard Medical School and practices at Boston Children's Hospital. His research laboratory focuses on the molecular pathogenesis of infections caused by parasites, specifically investigating the replication of Plasmodium falciparum within human red blood cells. The primary goal of his lab is to identify fundamental biological processes in the parasite life cycle, particularly those involved in egress, which is crucial for the proliferation of malaria. His work has demonstrated that the calcium-dependent protein kinase PfCDPK5 is essential for parasite replication, with a knockdown of this gene blocking late-stage development prior to egress. Current projects aim to elucidate the specific molecular mechanisms of PfCDPK5 and characterize other calcium-responsive signaling pathways that regulate parasite replication. Dvorin's lab employs advanced genetic, cell biological, and molecular biology techniques to explore roles of novel proteins in calcium signaling pathways and to discover essential genes required for asexual replication of P. falciparum.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.