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Jeff Henderson’s research focuses on the molecular mechanisms governing programmed cell death (PCD) pathways in mammalian brain stem cells under normal and pathological states. This includes understanding PCD processes such as apoptosis and necroptosis, which play critical roles in controlling cell death in states like spinal cord injury and neurodegenerative diseases. The laboratory is discovering new molecular interactions regulating PCD signaling, including key protein-protein interactors targeted for small molecule therapeutics. Henderson’s work also examines axon guidance and the survival of neurons, investigating the EphB family of signaling molecules and their role in neuron connectivity and functional recovery in the central nervous system. His laboratory employs innovative techniques such as stem cell-mediated CRISPR gene targeting to explore gene modifications that impact PCD and neuronal health.
Department of Sociology