Dr. Jeffrey Macklis

Biography

Jeffrey Macklis is the Max Anne Wien Professor in the Department of Stem Cell and Regenerative Biology at Harvard University. His research focuses on understanding the molecular controls governing neuron subtype development and diversity, alongside axon guidance and circuit formation related to degeneration and disease in the cerebral cortex. Specific areas of interest include corticospinal motor neurons and related motor neuron diseases such as ALS, hereditary spastic paraparesis, and primary lateral sclerosis. Macklis's laboratory also works on applying developmental mechanisms to brain and spinal cord regeneration and the directed differentiation of neuronal subtype using pluripotent stem cells. His research themes often explore the relationship between cortical development, evolution, disease, and regeneration. Macklis is involved in extensive collaborations and has a broad impact in the fields of neuroscience and regenerative medicine.

Research Interests