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The Rathmell lab aims to identify the metabolic pathways and nutrient microenvironments that regulate lymphocyte metabolism, differentiation, and function. The activation of T lymphocytes remodels cellular metabolism to support cell growth, proliferation, and signaling essential for effector differentiation and function. His field of research, immunometabolism, explores mechanisms of metabolic reprogramming and how metabolic pathways influence immune cell fate and function. The Rathmell lab employs genetic and metabolic techniques to discover mechanisms by which obesity affects cancer immunotherapy and how inflammatory microenvironments shape immune cell metabolism.
Department of Philosophy