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Jennifer Cobb is an Adjunct Professor in the Department of Biochemistry & Molecular Biology at the University of Calgary. Her research primarily focuses on cancer genetics, especially the role of chromosomal instability in the early stages of tumorigenesis. She studies RecQ helicases, which are essential for maintaining genomic integrity; loss of RecQ function can lead to a heightened risk of cancer. Utilizing Saccharomyces cerevisiae as a model organism, she investigates the molecular mechanisms by which RecQ helicases function to preserve genome stability. Her work examines the relationship between the Sgs1-MRX complex and RecQ helicases, particularly in the context of fragile site stability and slow-replicating regions of the genome. She is keen to understand how checkpoint activation occurs during the S phase of the cell cycle, focusing on the roles of Mec1-Ddc2 (the human ATR-ATRIP equivalent) in stabilizing stalled replication forks and the related signaling pathways.
Department of Computer Science Master's program. GRE scores are expected for international students.