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Dr. Schlezinger’s expertise is in molecular toxicology with a focus on environmental toxicants that disrupt physiological function through ligand-activated transcription factors. Her early career focused on the activation of the aryl hydrocarbon receptor (AhR) by polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls. In collaboration with immunologist Dr. David Sherr, she determined that PAHs suppress B lymphocyte development and impair immune function. She has led the introduction of nuclear receptors into her research, investigating the effects of peroxisome proliferator-activated receptor (PPAR) ligands on B cell development, finding that they directly act on developing B cells and alter the bone marrow microenvironment, skewing multipotent cell differentiation towards bone and adipose formation. Over the past decade, her lab has been dedicated to understanding how environmental toxicant exposure impairs bone, liver, and adipose homeostasis, laying a foundation for studying osteoporosis and metabolic disease. Her recent work includes investigating the effects of perfluoroalkyl substances (PFAS) on the activation of various nuclear receptors and their consequences on metabolic and bone health, as well as the interaction between SARS-CoV-2 infection and PFAS exposure.
Department of Law offers JD, LLM, and Master's in Study of Tax Law.