Dr. Jens Christian Meiners

Biography

Professor Meiners investigates experimental dynamics of single DNA molecules and DNA-protein complexes using optical single molecule techniques. His research emphasizes the understanding of the topology of DNA molecules, which can manifest in forms such as linear, circular, knotted, and supercoiled conformations. These topological characteristics significantly affect the dynamics of molecules and their interactions with regulatory proteins, ultimately influencing biological functions. His laboratory employs laser-trapping techniques to directly manipulate single DNA molecules to study their dynamics. One of the innovative methods developed in his research is a novel optical-tweezer based force measurement technique known as femtonewton force spectroscopy, which allows for the measurement of ultra-small force fluctuations at millisecond time resolution. This technique provides unprecedented insight into the dynamics of molecules. By combining optical methods with modern microfabrication techniques, his group creates microfluidic chips made from silicon elastomers. This advanced approach greatly enhances the capabilities to study a wide range of DNA-protein interactions and sheds light on fundamental biological processes, such as transcriptional regulation of gene expression. Professor Meiners is an Alfred P. Sloan Research Fellow as recognized by the Alfred P. Sloan Foundation.

Research Interests

Experience