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Dr. Jeremy Chien is a professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis. His laboratory focuses on applied genomics and cancer therapeutics, particularly in understanding biological pathways that lead to ovarian cancer. Through the Chien Laboratory, new therapeutic strategies are developed, targeting critical vulnerabilities in ovarian cancer cells, such as mutations in the TP53 gene, which is common in high-grade serous ovarian cancer. His research integrates genomic approaches to explore driver genes and synthetic lethality for targeted therapies, enhancing the efficacy of existing treatments like PARP inhibitors. Chien's work on metabolic vulnerabilities in cancer cells highlights the importance of tumor microenvironments and biological pathways like the FOXM1/MYC nexus and the TGF-β pathway in chemotherapy resistance. He also investigates how certain strategies can induce 'BRCAness' in cancer cells to facilitate targeted treatment. Chien has a rich publication record with numerous articles contributing significantly to the fields of oncology, genomic stability, and cancer resilience mechanisms.
University of California, Davis • Sacramento, CA
Teaching and conducting research in Biochemistry and Molecular Medicine.
Department of Computer Science. GRE is NOT required.