Dr. Jeremy Wang

Biography

Dr. Jeremy Wang is the President's Distinguished Professor and Director of the Center for Animal Transgenesis & Germ Cell Research at the University of Pennsylvania's Department of Biomedical Sciences. His research focuses on the study of meiosis and spermatogonial stem cells, with an emphasis on the mechanisms that regulate genetic diversity during reproduction. His work has uncovered important insights into how spermatogonial stem cells contribute to male fertility and the genetic factors that can lead to male infertility in humans. Dr. Wang's laboratory investigates the roles of piwi-interacting RNAs (piRNAs) in safeguarding genome integrity and the fundamental processes governing homologous recombination during meiosis. His findings on the essential functions of DOT1L and MOV10L1 in spermatogonial stem cell self-renewal and piRNA biogenesis have significant implications for understanding male reproductive health and developing novel contraceptives. Through genome-wide proteomics, his research has identified critical meiotic factors, advancing the field's knowledge of genetic regulation in male germ cells.

Research Interests

Experience