Dr. Jerome Gouge

Biography

Jerome Gouge is a Senior Research Fellow in the Department of Structural & Molecular Biology at University College London. He holds a Ph.D. in Structural Biology from the Pasteur Institute in Paris, where his research focused on the structural rearrangements that occur in DNA polymerases during DNA replication. His notable work utilizing X-ray crystallography has unravelled the activity of DNA polymerases in the presence of non-canonical substrates, which include abasic sites and oxidized bases leading to double-strand breaks. Following his postdoctoral studies at the Institute of Cancer Research in London, he concentrated on the recruitment mechanisms of RNA polymerase III to type 3 promoters, solving the crystal structure of the complex that recruits the polymerase and demonstrating the role of a redox-sensing module in regulating transcriptional output. In 2020, he established his own research group at Birkbeck College, University College London, under the Sir Henry Dale Fellowship from the Wellcome Trust, where he employs a combination of structural, biophysical, and cellular techniques to characterize the molecular mechanisms underlying oxidative stress responses in higher eukaryotes.

Research Interests

Experience