Dr. Jesper Svejstrup

Biography

Jesper Qualmann Svejstrup is a Professor at the University of Copenhagen, where he researches the molecular mechanisms of transcription, a fundamental cellular process that interfaces with DNA-related processes such as replication and repair. His work has highlighted how the deregulation of gene expression can lead to diseases such as cancer, particularly through the activation of previously inactive genes and the inherent instability of cancer cell genomes. He utilizes a combination of biochemical, genetic, and cell biological techniques to investigate how transcription affects genome integrity, especially focusing on transcription-coupled DNA repair processes, which rectify DNA damage that impedes RNA polymerase II transcription. His laboratory has significantly advanced understanding of how cells cope with the damaging effects of transcription on genomic stability. Additionally, Svejstrup has explored the regulatory pathways involved in DNA repair and transcriptional responses to DNA damage, applying proteomics and genomics to uncover new factors critical for these mechanisms.

Research Interests

Experience

Awards