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The Dunaief Lab is focused on understanding age-related macular degeneration (AMD), a leading cause of irreversible blindness globally, particularly among the elderly. The lab, established in 2003, investigates how elevated iron levels and inflammation contribute to AMD and other neurodegenerative diseases. The research team, composed of ophthalmologists, research fellows, and graduate students, employs cutting-edge basic science to prevent vision loss and improve patient outcomes. The lab's work is part of the F.M. Kirby Center for Molecular Ophthalmology at the University of Pennsylvania, where groundbreaking research into the pathophysiology of AMD is being conducted. Notable findings include the progression of AMD through stages such as geographic atrophy and choroidal neovascularization, with ongoing efforts to address the iron-inflammation nexus in retinal degenerations.
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