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Jesse Zalatan studies the physical organizing principles of biological networks in cellular signaling, metabolism, and gene regulation. His lab employs a variety of methods from physical organic chemistry, mechanistic enzymology, biochemistry, and synthetic biology. Jesse completed his graduate work at Stanford University from 2002 to 2008, where he developed comparative models to understand the mechanisms of evolution of enzymes that catalyze phosphoryl transfer reactions. In 2008, he moved to UCSF to join the laboratory of Wendell Lim, focusing on mechanisms that control the specificity of cellular signaling networks and developing CRISPR-Cas tools for programmable control of gene expression networks. He joined the chemistry faculty at the University of Washington in 2014.
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