Dr. Jianxin Jian

Biography

Jianxin Jian is a Professor in the Department of Microbiology at the Perelman School of Medicine, University of Pennsylvania. His research primarily focuses on oncogenic virus-driven tumorigenesis, specifically investigating the molecular interplay of oncogenic viruses such as Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) and their contributions to cancer development. With a Ph.D. from Johns Hopkins University and a postdoctoral training at Harvard Medical School, his work addresses critical aspects of cancer immunotherapy, particularly the role of STING (Stimulator of Interferon Genes) in eliciting antiviral and antitumor innate immunity. His laboratory aims to develop innovative therapeutic strategies against pathogenic viral infections and tumor development. Significant contributions include elucidating mechanisms of MCPyV replication and developing strategies to enhance immune responses against tumors that are currently resistant to existing therapies. Dr. Jian is actively engaged in creating new antiviral drugs targeting HPV and its interactions with host cells to treat persistent infections and prevent HPV-associated cancers.

Research Interests

Experience