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Jianzhu Chen studies the immune system, harnessing the body’s defense forces to explore treatment and prevention of cancer, as well as metabolic and infectious diseases. His research seeks to understand the immune system and its application in cancer immunotherapy and vaccine development. He studies the molecular and cellular mechanisms of immunological disease processes, leveraging a vast array of genomic data, humanized mice, and clinical samples. His contributions to the field of integrative cancer research are significant due to his innovative approach to understanding complex biological systems.