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JoAnne Stubbe is a Visiting Scholar at Harvard University in the Department of Chemistry and Chemical Biology. Her research focuses on ribonucleotide reductases (RNRs), which are crucial for the conversion of nucleotides to deoxynucleotides and play an essential role in DNA replication and repair. She supports a range of ongoing projects related to the radical propagation pathways utilized by Class RNRs, the interactions of protein subunits within Class RNRs, and the regulation mechanisms of RNRs, including the impact of clinical drugs. Stubbe also examines the biosynthesis, activation, and regulation of the formation of essential metallo-cofactors in RNRs across various organisms, including E. coli, Saccharomyces cerevisiae, and humans.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).