Dr. Joel Pomerantz

Biography

Joel L. Pomerantz is an Associate Professor in the Department of Biological Chemistry. His research focuses on the molecular mechanisms by which cells interpret signals from their environment, influencing processes such as proliferation, differentiation, and apoptosis, which are vital for the development and functioning of the immune system. Dysregulation of signal transduction is linked to various immune-related diseases, including immunodeficiencies, autoimmunity, and cancers. Notably, Pomerantz's lab investigates the regulation of NF-κB, a crucial transcription factor in innate and adaptive immunity that can become improperly activated in certain cancers. His team studies how NF-κB is activated in B and T lymphocytes in response to antigen recognition via T cell receptor and B cell receptor complexes. Current research aims to understand the functionality of the multi-domain adapter protein CARD11 within TCR signaling and its role in NF-κB dysregulation associated with Diffuse Large B cell Lymphoma (DLBCL). Pomerantz's work hopes to uncover mechanistic insights that could inform the development of novel cancer therapeutics, in addition to expanding the understanding of signaling molecules involved in controlling immune responses.

Research Interests