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John Alverdy is a prominent physician specializing in surgery and the molecular interactions between bacteria and the intestinal mucosa. His research focuses on understanding life-threatening infections that arise from trauma, major surgeries, and critical illnesses. He leads a continuously NIH-funded laboratory that develops anti-infective, polymer-based compounds to attenuate the virulence of multi-drug resistant pathogens in surgical patients. The Alverdy lab investigates the regulation of virulence expression in potential pathogens, particularly Pseudomonas aeruginosa, and examines the microbial context and molecular mechanisms that contribute to disease. Dr. Alverdy also researches the applications of these findings in intestinal transplantation, radiation physiology, and necrotizing enterocolitis. He is dedicated to developing virulence-based therapies aimed at preventing virulence activation in stressed hosts, utilizing computational agent-based modeling to dynamically represent mechanisms of these interactions at cellular and tissue levels.
Michael Reese Hospital Medical Center • Chicago, IL
Completed residency in Surgery.
University of California, San Francisco • San Francisco, CA
Completed fellowship specializing in trauma and burn care.
Department of Philosophy