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John Alverdy, MD, runs a continuously funded NIH laboratory focused on studying the molecular interactions between bacteria and intestinal mucosa to understand life-threatening infections that arise from trauma, major surgery, and critical illness. He has developed anti-infective polymer-based compounds to attenuate the virulence of multi-drug resistant pathogens responsible for infections in surgical patients. His research seeks to understand the regulation of virulence expression in potential pathogens by investigating the characteristics of microbial context and the molecular machinery that senses this context. A significant portion of his work has focused on the virulence mechanisms of Pseudomonas aeruginosa, a clinically important pathogen, demonstrating that these organisms can respond to host environmental cues related to stress and immune activation. Alverdy's lab is also interested in the applications of this research in intestinal transplantation and therapies to prevent virulence activation in stressed hosts. Additionally, he employs computational agent-based modeling to dynamically represent the mechanistic details that recapitulate cellular behavior. His ultimate goal is to develop clinical tools that improve patient care through a better understanding of microbial virulence.
University of Chicago • Chicago, IL
Lead research and teaching in the field of surgery, focusing on infectious diseases and their microbial basis.
Department of Philosophy