Dr. John Alverdy

Biography

John Alverdy is the Sara & Harold Lincoln Thompson Professor of Surgery at the University of Chicago, where he leads a continuously funded NIH-backed laboratory focused on the molecular interactions between bacteria and the intestinal mucosa. His research aims to understand how life-threatening infections arise from trauma, major surgery, and critical illness, and he has developed anti-infective polymer-based compounds to mitigate the virulence of multi-drug resistant pathogens that pose significant risks to surgical patients. Alverdy's lab investigates the regulatory mechanisms of virulence expression in potential pathogens, with a focus on Pseudomonas aeruginosa, a clinically relevant pathogen known to respond dynamically to host environmental cues. His broader interests include advancing virulence-based therapies that can prevent pathogenic activation in stressed hosts. Alverdy's academic contributions extend to the evolution of computational modeling techniques that represent the complexities of host-pathogen interactions, facilitating insights at tissue and organ levels.

Research Interests

Experience