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John Chambers focuses his research on the investigation of genetic and environmental mechanisms underlying obesity, diabetes, and cardiovascular disease related phenotypic disturbances in Indian Asians. He has collaborated closely with notable professors to establish the London Life Sciences Population (LOLIPOP) study, one of the largest cohort studies of Indian Asians worldwide. His recent work has capitalized on this unique population cohort to provide new insights into the mechanisms influencing obesity, diabetes, and cardiovascular disease in human phenotypes. Key outputs from his research include the identification of MLXIPL as a key determinant of plasma triglyceride levels, and demonstrating that common genetic variants near the hypothalamic receptor MC4R are associated with central obesity and insulin resistance. His findings indicate that risk-allele frequencies are higher in Indian Asians compared to Europeans, suggesting a genetic mechanism that contributes to the increased burden of central adiposity and insulin resistance in this population. Furthermore, he has identified genetic loci that influence kidney function and risk of chronic kidney disease.
Specialisms available in Materials for the Energy Transition or Theory and Simulation of Materials.