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John Coles is a professor in the Department of Surgery at the University of Toronto, specializing in cardiac surgery. He holds an M.D. and is a Fellow of the Royal College of Surgeons of Canada. Dr. Coles’ research focuses on xenotransplantation, particularly addressing the mechanisms of hyperacute rejection in human-porcine xenogeneic systems, where he has identified critical roles for programmed cell death in mediating endothelial cell injury in response to xenogeneic stimuli. His lab aims to develop anti-apoptotic strategies to mitigate hyperacute rejection, and offers research training programs for Master’s and Ph.D. students. Coles also has clinical responsibilities in the Division of Cardiovascular Surgery at the Hospital for Sick Children, with a keen interest in complex congenital heart disease and conducting clinical research involving epidemiological and biostatistical analyses.
University of Toronto • Toronto, Ontario, Canada
Professor in the Department of Surgery specializing in cardiac surgery.
Hospital for Sick Children • Toronto, Ontario, Canada
Clinical appointment in the Division of Cardiovascular Surgery focusing on complex congenital heart disease.
Department of Sociology