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John Denu is a Professor in the Department of Biomolecular Chemistry and Director of the Metabolomics Core at the University of Wisconsin–Madison. His research focuses on the interplay between metabolism and epigenetic states, particularly how reversible protein modifications influence signal transduction and chromatin dynamics in metabolic processes. His lab has pioneered proteomic methods to investigate protein modifications in both histone and non-histone proteins, providing insights into novel mechanisms that govern metabolism through acetylation and methylation pathways. His work emphasizes the impact of metabolic stress, including factors such as diet, obesity, and diabetes, on chromatin methylation and acylation states. Current major projects in his lab include research on how metabolism is linked to epigenome regulation, the role of NAD+-dependent deacylases in aging and metabolic diseases, the effects of epigenome dysregulation on age-related diseases, and the influence of gut microbial metabolites on host phenotypes.
Department: Department of Computer Sciences