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John DiGiovanni is a professor at the University of Texas at Austin's College of Pharmacy, where he holds the Coulter R. Sublett Chair and directs the CMCT Research laboratory. His research has centered on understanding cancer development through novel target identification and environmental influences on genetic factors, which are crucial for devising effective cancer prevention strategies. His laboratory studies cellular and molecular changes that occur when normal cells transform into cancerous cells, a key area in eradicating cancer, a leading human disease. Ongoing projects focus on identifying disrupted cellular signaling pathways in tumor progression, including PI3K/Akt/mTOR and Stat pathways. His research also identifies genes linked to susceptibility to environmentally-induced cancers, employing genetic models to map these influences. DiGiovanni's studies extend to the role of obesity in cancer development, examining how obesity alters growth factor signaling and its contribution to various cancers, including skin, prostate, and head and neck cancers.
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