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John Marshall is a Professor in the Department of Medical Science at Brown University. His research focuses on the regulation of glutamate receptors, which play critical roles in neuronal communication. Malfunctions in regulating these receptors are associated with various neurodegenerative diseases, including Alzheimer's, Huntington's, and Parkinson's. Through his research, he aims to identify proteins that control the localization of receptors at synapses and to design drugs that prevent neuronal death in these disease states. His studies also delve into Angelman syndrome, a severe neuro-genetic disorder, where he analyzes the impairments in BDNF/TrkB receptor signaling that affect cognitive functioning. Marshall has identified the synaptic scaffolding protein PSD-95 as a novel drug target within the BDNF signaling pathway and has developed a cyclic peptide drug, CN2097, to enhance BDNF signaling and improve long-term potentiation in mice. His work has significant implications for therapeutic interventions in neurodegenerative disorders and intellectual disabilities associated with defective synaptic strength.
Brown University • Providence, RI
Professor in the Department of Medical Science with a focus on research and teaching.
Department: Department of Economics