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John McGuire is a researcher specializing in Cardiovascular Pharmacology and Physiology, focusing on understanding endothelial function and dysfunction in models of cardiovascular disease. His work involves the use of isometric tension microelectrode recordings of isolated blood vessels from transgenic inbred animals. McGuire examines long-term blood pressure and heart rate monitoring in conscious mice using radiotelemetry techniques. His research aims to explore mechanisms linking endothelial cells to vascular smooth muscle cell function, especially in conditions of endothelial dysfunction. His lab investigates signaling pathways, particularly through Proteinase-Activated Receptor 2 (PAR2), that contribute to the regulation of vascular smooth muscle tone. Understanding these mechanisms is crucial in the development of therapeutic targets for cardiovascular diseases.
Memorial University of Newfoundland • St. John's, NL
Leading research in cardiovascular systems focusing on endothelial and vascular smooth muscle interactions.
Department of Business Administration (MBA program)