Dr. John O Brien

Biography

Professor John O’Brien leads the Old Age Psychiatry Research Group at the University of Cambridge's Department of Psychiatry. His research focuses on the study of dementia, particularly Lewy body dementia. He employs various methodologies to enhance the diagnosis and management of these disorders. Utilizing multi-modal imaging techniques such as MRI, MEG, and novel PET fluid markers, he investigates the pathophysiological processes and aims to develop biomarkers for disease progression. His studies also encompass a range of dementia cases throughout life, including Lewy body dementia, Alzheimer's disease, vascular dementia, and the prodromal stages of these conditions. Additionally, he closely explores related issues such as late-life depression. Professor O'Brien maintains strong collaborations with various departments within Cambridge, particularly with Clinical Neurosciences, and the Cambridge Biomedical Research Centre, as well as with the Cambridgeshire and Peterborough NHS Foundation Trust. He actively collaborates with national and international groups through frameworks such as the Dementias Platform UK, the NIHR Dementia Translational Research Collaboration, and the European DLB Group and International DLB Consortium.

Research Interests