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Professor John Pimanda is a distinguished researcher at the University of New South Wales, specializing in molecular cell biology with a focus on blood development and leukemia. His research agenda is centered around studying genome-wide changes in healthy and leukemic blood stem cells at single-cell resolution. His work aims to enhance the understanding and management of blood stem disorders, particularly myelodysplasia (MDS) and acute myeloid leukemia (AML). Professor Pimanda's interests include identifying critical components of the hematopoietic transcriptional network that govern 'stemness'. Additionally, he explores how this network is perturbed in mutant blood stem cells, the impacts of mutations, and clonal dominance in the maintenance of leukemia. His investigations also extend to the role of stromal and immune cells in the development of blood stem cells and their maintenance in leukemic patients.
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