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John F. Rawls is the James B. Duke Distinguished Professor in the Department of Molecular Genetics and Microbiology. His research focuses on understanding the intestinal microbiome and its contributions to vertebrate physiology and disease. He utilizes zebrafish and mouse models to study host-microbiome interactions and has identified conserved mechanisms by which intestinal bacteria regulate dietary fat metabolism and systemic innate immunity. Dr. Rawls applies genomic approaches to understand transcriptional regulatory pathways in the intestinal epithelium that mediate host responses to the microbiome. His work has revealed mechanisms of transcriptional chromatin regulation that are conserved throughout vertebrate evolution and contribute to modern human diseases, including inflammatory bowel diseases, obesity, and diabetes. His research program is dedicated to uncovering ancient mechanisms of host-microbiome interactions present in various animal taxa, which can inform therapeutic strategies for human diseases.
Duke University • Durham, NC
Leading research in molecular genetics and microbiology, focusing on the gut microbiome.
Duke University • Durham, NC
Conducting advanced research and teaching in molecular genetics and microbiology.
Duke University • Durham, NC
Teaching courses in molecular genetics and microbiology.
Department of Biomedical Engineering (MS program)