Dr. John Sherman

Biography

Professor John Sherman specializes in the design and synthesis of organic and biological molecules with well-defined structures. His research delves into the creation of new systems known as hybrid cavitand-proteins, or 'caviteins'. These de novo proteins consist of four alpha-helical peptide chains assembled around a rigid bowl-shaped organic macrocyclic cavitand molecule. This configuration allows for the formation of a hydrophobic cavity that can selectively bind guest molecules. Sherman's research explores various aspects of molecular recognition, protein folding, and reaction mechanisms, particularly in the context of creating carceplexes. These complexes entrap smaller molecules within closed-surface organic structures, which could lead to novel applications in drug delivery. His work also includes the study of self-assembling structures and their applications in materials science. Techniques utilized in his lab include organic synthesis, peptide synthesis, and various analytical methods such as HPLC and NMR.

Research Interests

Experience