Dr. John Straub

Biography

John Straub explores protein dynamics and thermodynamics using theoretical computational methods, focusing on elucidating pathways of conformational change associated with protein energy transfer, signaling, folding, and aggregation. His research group investigates fundamental aspects of protein dynamics and thermodynamics underlying the formation of protein structure and function. Students and postdoctoral researchers collaborate in developing and employing state-of-the-art computational methods alongside leading experimental research groups. His pioneering studies elucidate kinetic and thermodynamic properties defining protein aggregation, particularly at the earliest stages of amyloid protein aggregation. His work has resulted in novel computational algorithms that enhance sampling of conformational ensembles in complex biomolecular systems, facilitating direct simulations of dynamics that support energy flow associated with protein functions. He is the co-editor of the book “Proteins: Energy, Heat Signal Flow,” which captures contemporary theoretical studies related to protein dynamics and signaling.

Research Interests

Experience

Awards