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E. John Wherry is the Richard Barbara Schiffrin President's Distinguished Professor at the Perelman School of Medicine at the University of Pennsylvania. He earned his Bachelor of Science in Science from Pennsylvania State University in 1993 and completed his PhD in Immunology at Thomas Jefferson University in 2000. Wherry's research focuses on T cell exhaustion, immunotherapy, and immune health. His work has significantly advanced the understanding of T cell biology in the context of chronic infections and cancer, particularly the mechanisms driving T cell exhaustion and the pathways that can reinvigorate these cells through checkpoint blockade. His laboratory employs high-dimensional immune profiling, genomics, and epigenetic approaches to explore immune regulation and responses to therapy. The lab is dedicated to understanding the dynamics of immune cells in various settings, including their regulation in response to viral infections and cancer therapies. Wherry has authored numerous publications that contribute to the field of immunology and actively plays a vital role in mentoring the next generation of scientists in advancing research in this critical area of medicine.
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